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KMID : 0616120190500020141
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 2 p.141 ~ p.147
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Antioxidant and antidiabetic effects of leaves and stems of Acanthopanax sieboldianum (Makino) Koidz
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Kim Sang-Jun
Kim Ji-Ae
Kim Sol
Youn Jong-Ung
Kim Hong-Seok
Han Sang-Sub
Kim Seon-Young
Jeong Seung-Il
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Abstract
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The aim of this study was to investigate the potential of Acanthopanax sieboldianum (Makino) Koidz (ACS) as a potent antioxidant and antidiabetic agent. The antioxidative and alpha-glucosidase inhibitory activities were examined using the methanol extracts and solvent fractions from ACS-leaf and ACS-stem. Antioxidative activities were measured by in vitro methods such as DPPH and ABTS radical scavenging activity and superoxide dismutase (SOD) activity. When the chloroform and ethyl acetate fractions of ACS-leaf and ethyl acetate fractions of ACS-stem were compared with the control, the SOD-like activity was impaired even at the low treatment concentrations. In addition, the ethyl acetate fractions of ACS-leaf and ACS-stem showed alpha-glucosidase inhibition activities at low treatment concentrations. Analysis of the major components in the fractions of ACS-leaf and ACS-stem was also performed using HPLC. Finally, astragalin, isoqurecetin, chlorogenic acid and caffeic acid contents were measured. Based on this work, we propose that ACS-leaf and ACS-stem have great potential as natural antioxidant and antidiabetic materials related to health benefits.
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KEYWORD
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Acanthopanax sieboldianum (Makino) Koidz, Diabetes mellitus, alpha-Glucosidase, Antioxidant
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